Evidence based medicine

These gene mutations are relatively common. C677T variant.

The mutations can lead to high levels of homocysteine in the blood, which may contribute to health conditions, including birth anomalies and coronary heart disease.

Brain-derived neurotrophic factor (BDNF) as well as nerve growth factor (NGF) where they are involved in the development and maintenance of physiological brain functions.

Alterations of NTF expression, including BDNF, are involved in the development of a variety of CNS diseases, including neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, lupus) as well as psychiatric disorders (depression and schizophrenia). NTFs may be considered therapeutic targets, but their use has been limited so far by several, still unresolved, methodological problems aimed to guarantee their safety and efficacy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804326/

Curcumin supplementation can increase brain-derived neurotrophic factor (BDNF) levels in the serum. BDNF is important for normal neuronal function, energy homeostasis, and cognitive function. Curcumin's ability to increase BDNF levels may have potential applications for neurological disorders that are associated with low BDNF levels.